Directions for use:

Take one (1) serving per day one (1) hour before bed, preferably on an empty stomach. Do not exceed stated dose.
May cause drowsiness. Do not consume during daytime hours, or when operating machinery, or when driving.

Magnesium

Magnesium is an essential mineral responsible for various different biological actions including the metabolism of ATP, electrolyte function, and is a significant structural element in DNA and other tissues of the body. In addition, Magnesium also plays a key role in the regulation of sleep, sleep time, and sleep efficiency. Furthermore, numerous studies also demonstrate Magnesium’s capacity to reduce serum cortisol concentration.

Zinc

The trace mineral Zinc is an important micronutrient that is essential for the maintenance of good health.  For example, adequate levels of Zinc are necessary for proper immune system function.

With a multitude of other physiological effects, Zinc also appears to be an important co-factor in sleep quality with emerging evidence consistently demonstrating that oral zinc supplementation may increase both the duration and the quality of sleep.

Pantothenic Acid

Pantothenic acid otherwise known as vitamin B-5 is a water soluble vitamin that amongst its other physiologic actions is used as a substrate in the synthesis of coenzyme A (CoA).

CoA plays a key role in the structure and function of brain cells as a result of its participation in the synthesis of phospholipids and fatty acids.

With regard to sleep, Pantothenic acid is of particular relevance due to its connection in the synthesis of multiple neurotransmitters.

Vitamin B-6

Vitamin B-6 is an important co-factor in energy metabolism but is also proposed to contribute to better sleep because of its status as a rate-limiting factor in the synthesis of sleep sensitive neurotransmitters with particular regard to GABA, serotonin, and melatonin.

In fact even a moderate deficiency in vitamin B-6 can lead to the down-regulation in production of serotonin and GABA and consequently disordered sleep.

Vitamin B-12

Vitamin B-12 is vital component in the generation of cellular energy and is also an essential factor in the synthesis of DNA. It is proposed that vitamin B12 deficiency is connected with insomnia as a consequence of its involvement in the pathophysiology of depression.

DNA Lean Delta-Mynd contains 100% of the recommended daily allowance of vitamin B-12.

Folate

Folate exhibits potent anti-oxidant properties, protects against DNA damage, and is of significant importance in the reduction of inflammation with particular reference to the homocysteine inflammatory marker.

With respect to sleep, Folate is a co-factor in the biosynthesis of Melatonin from N-Acetyl-Serotonin.

Additionally, folate elicits biological effects in conjunction with pantothenic acid, vitamin B-6, and vitamin B-12. Evidence also suggests a link between folate deficiencies and sleep disturbance.

Biotin

Biotin is a member of the B-vitamin family and is responsible for a wide range of physiological processes including its function in cellular mitochondria where it is essential in the metabolism of glucose, fatty acids, and amino acids.

Valerian Root (Valeriana Officinalis) Extract

Valeriana officinalis is a perennial flowering European plant that bears sweet smelling pink or white flowers, lending its name from the root Latin word; valere, meaning -to be strong.The roots of the plant contain a wide spectrum of biologically active nutrients, including the alkaloids, valerianine, and valerine, the flavanone hesperidin, and Gamma-amino-butyric acid (GABA).

Valerian root has been used as an herbal remedy for a wide spectrum of purposes including sedation. Today, science proposes that Valerian root extract does have a potential mechanism of sedation via its action on the GABA_A receptor which is responsible for inhibition of the central nervous system (CNS).

Lemon Balm (Melissa Officinalis) Extract

Lemon balm or balm mint is a perennial plant in the mint family with mild lemon scented leaves that have been used for at least a thousand years in herbal teas and other alternative medicinal preparations.

It is of notable interest that Paracelsus, a Swiss physician from the 15^th century referred to Lemon Balm as the "elixir of life" as he believed lemon balm had the power to restore a person’s health.

Today various clinical trials support the potential use of Lemon Balm for improving sleep quality by reducing stress.

5-HTP (Griffonia Simplicoifolia)

Griffonia simplicifolia is a woody climbing plant found in western regions of Africa whose seeds naturally contain 5-HTP (5-hydroxy-tryptophan).

5-HTP is precursor and a rate-limiting factor in the synthesis of the body’s master hormone melatonin. Melatonin is at the top of the hormone cascade and is responsible for the regulation the sleep/wake cycle.

It is also involved in the regulation of other hormones downstream of it, such as human growth hormone, testosterone, and estrogens. Decreased levels of melatonin are associated with ageing.

Passionflower (Passiflora Incamata) Extract                   

Passion flowers belong to the family Passifloraceae and are a genus of over five hundred species of flowering plants with a hallmark corona.

These distinctive flowering plants have purportedly been used in traditional herbal medicine as sedatives, anxiolytic treatments, and as a popular sleeping aid over a course of at least several hundred years.

Today an abundance of clinical investigations demonstrate the potential sedative effects of Passiflorae herba and as a result is widely considered as herbal sleep inducer.